A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis

This study demonstrates that FGF10/FGFR2b signaling on distal epithelial progenitor cells, via ß-catenin/EP300, controls, through a comprehensive set of developmental genes, morphogenesis, and differentiation. Fibroblast growth factor (FGF) 10 signaling through FGF receptor 2b (FGFR2b) is mandatory...

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Bibliographic Details
Main Authors: Matthew R. Jones, Salma Dilai, Arun Lingampally, Cho-Ming Chao, Soula Danopoulos, Gianni Carraro, Regina Mukhametshina, Jochen Wilhelm, Eveline Baumgart-Vogt, Denise Al Alam, Chengshui Chen, Parviz Minoo, Jin San Zhang, Saverio Bellusci
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
FGF10
FGFR2b
lung
branching morphogenesis
differentiation
ß-catenin
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00746/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00746/full

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