Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02018-z |