Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease

Abstract Background The complex pathophysiology of Alzheimer’s disease (AD) hampers the development of effective treatments. Attempts to prevent neurodegeneration in AD have failed so far, highlighting the need for further clarification of the underlying cellular and molecular mechanisms. Neuroinfla...

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Bibliographic Details
Main Authors: Gonzalo Ruiz-Pérez, Samuel Ruiz de Martín Esteban, Sharai Marqués, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Rosa M. Tolón, María Posada-Ayala, Benjamin F. Cravatt, José A. Esteban, Julián Romero, Rocío Palenzuela
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Anandamide
Hippocampal synaptic plasticity
Dendritic spines
TREM2
Complement
Online Access:https://doi.org/10.1186/s12974-021-02276-y

Internet

https://doi.org/10.1186/s12974-021-02276-y

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