An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens

The era of antibiotics as a cure-all for bacterial infections appears to be coming to an end. The emergence of multidrug resistance in many hospital-associated pathogens has resulted in superbugs that are effectively untreatable. Multidrug efflux pumps are well known mediators of bacterial drug resi...

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Bibliographic Details
Main Authors: Karl A Hassan, Liam DH Elbourne, Liping eLi, Hasinika KA Hewawasam Gamage, Qi eLiu, Scott M Jackson, David eSharples, Anne-Brit eKolstø, Peter JF Henderson, Ian T Paulsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Microbiology
Subjects:
Transcriptomics
multidrug efflux systems
Bacterial drug resistance
Adaptive resistance
bacterial transmembrane pair
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00333/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00333/full

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