Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor.
Thyroid eye disease (TED) can lead to scar formation and tissue remodeling in the orbital space. In severe cases, the scarring process leads to sight-threatening pathophysiology. There is no known effective way to prevent scar formation in TED patients, or to reverse scarring once it occurs. In this...
Main Authors: | Christine L Hammond, Elisa Roztocil, Richard P Phipps, Steven E Feldon, Collynn F Woeller |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0222779 |
Similar Items
-
Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment
by: Rachel H. Park, BA, et al.
Published: (2019-09-01) -
Microparticles engineered to highly express peroxisome proliferator-activated receptor-γ decreased inflammatory mediator production and increased adhesion of recipient monocytes.
by: Julie Sahler, et al.
Published: (2014-01-01) -
The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.
by: Alison M Heffer, et al.
Published: (2019-01-01) -
The Aryl Hydrocarbon Receptor Is Expressed in Thyroid Carcinoma and Appears to Mediate Epithelial-Mesenchymal-Transition
by: Sonia Moretti, et al.
Published: (2020-01-01) -
Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor
by: Nicholas Dopkins, et al.
Published: (2021-01-01)