Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase LC-MS analysis of tetrabenazine aci...

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Bibliographic Details
Main Authors: Laurent Ettouati, Zoé Senta-Loys, Sandrine Bourgeois, Bernard Fenet, Marc Le Borgne, Hatem Fessi
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
tetrabenazine
deuteration
deuterated tetrabenazine
synthesis
stability
degradation impurities
acid medium
LC-MS
orodispersible film
Online Access:https://www.mdpi.com/1999-4923/11/1/44

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https://www.mdpi.com/1999-4923/11/1/44

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