Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.

Bibliographic Details
Main Authors: Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12393-1

Internet

https://doi.org/10.1038/s41467-019-12393-1

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