A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acids, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high levels of 2-hydroxyglutarate (2-HG) levels. The aim of this study...

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Bibliographic Details
Main Authors: Xin Shen, Natalie L. Voets, Sarah J. Larkin, Nick de Pennington, Puneet Plaha, Richard Stacey, James S. O. McCullagh, Christopher J. Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, Olaf Ansorge, Uzay E. Emir
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Metabolites
Subjects:
glioma
isocitrate dehydrogenase
MR spectroscopy
metabolism
neurochemical profile
Online Access:https://www.mdpi.com/2218-1989/9/2/35

Internet

https://www.mdpi.com/2218-1989/9/2/35

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