Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

Inflammasomes are high molecular weight protein complexes in the cytosol of immune and other cells that play a critical role in the innate immune system in response to cellular stress. NLRP3 inflammasome, the best-understood inflammasome, is known to mediate the maturation (activation) of caspase-1...

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Bibliographic Details
Main Authors: Gong Chen, Mihail G. Chelu, Dobromir Dobrev, Na Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
NLRP3 inflammasome
innate immune system
cardiomyocytes
cardiac fibroblasts
cardiomyopathy
atrial fibrillation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01115/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01115/full

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