Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are essential for the maturation of a wide spectrum of proteins involved in various biological processes. In the ER, these enzymes work in concert to trim peptides for presentation on MHC class I molecules. Loss of ERAPs function sub...

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Bibliographic Details
Main Authors: Doriana Fruci, Franco Locatelli, Paolo Romania, Silvia Lorenzi, Loredana Cifaldi
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:International Journal of Molecular Sciences
Subjects:
endoplasmic reticulum aminopeptidases
MHC class I
antigen processing
autoimmunity
viral infection
cancer
cancer immunotherapy
Online Access:http://www.mdpi.com/1422-0067/13/7/8338

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http://www.mdpi.com/1422-0067/13/7/8338

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