The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis.

The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis.

BACKGROUND: The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. Mutations in the human MUTYH gene are responsible for colorectal cancer in familial adenomatous polyposis. Since defective DNA repair genes might contribute to the increased cancer risk associated with inflammator...

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Main Authors: Ida Casorelli, Tania Pannellini, Gabriele De Luca, Paolo Degan, Federica Chiera, Ivano Iavarone, Alessandro Giuliani, Alessia Butera, Monica Boirivant, Piero Musiani, Margherita Bignami
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2919403?pdf=render

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http://europepmc.org/articles/PMC2919403?pdf=render

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