Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the perspective of the gut microbiota, here, a chronic...

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Bibliographic Details
Main Authors: Jin-Bo Yu, Zhen-Xiong Zhao, Ran Peng, Li-Bin Pan, Jie Fu, Shu-Rong Ma, Pei Han, Lin Cong, Zheng-Wei Zhang, Li-Xin Sun, Jian-Dong Jiang, Yan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
paeoniflorin
pharmacokinetics
depression
gut microbiota
carboxylesterase
benzoic acid
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00268/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00268/full

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