Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation...

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Bibliographic Details
Main Authors: Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008195

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http://www.sciencedirect.com/science/article/pii/S2211124714008195

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