EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels

EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels

The exogenous Ca2+ chelator EGTA (ethylene glycol tetraacetic acid) has been widely used to probe the coupling distance between Ca2+ channels and vesicular Ca2+ sensors for neurotransmitter release. Because of its slow forward rate for binding, EGTA is thought to not capture calcium ions in very pro...

Full description

Bibliographic Details
Main Author: Yukihiro Nakamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Ca2+
Ca2+ channel
Ca2+ microdomain
reaction diffusion simulation
vesicular sensor
coupling distance
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2019.00026/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2019.00026/full

Similar Items