Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model

Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model

Abstract Background Cyclosporine A (CsA) is an essential immunosuppressant in organ transplantation. However, its chronic nephrotoxicity is an obstacle to long allograft survival that has not been overcome. Nuclear factor-κB (NF-κB) is activated in the renal tissue in CsA nephropathy. In this study,...

Full description

Bibliographic Details
Main Authors: Shinya Morita, Kazunobu Shinoda, Tadashi Yoshida, Masayuki Shimoda, Yoshihiko Kanno, Ryuichi Mizuno, Hidaka Kono, Hiroshi Asanuma, Ken Nakagawa, Kazuo Umezawa, Mototsugu Oya
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
Cyclosporine
Nephrotoxicity
NF-κB
NF-κB inhibitor
Online Access:http://link.springer.com/article/10.1186/s40360-020-00432-3

Internet

http://link.springer.com/article/10.1186/s40360-020-00432-3

Similar Items