Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex

Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex

Both donors and acceptors of communication-mediating (COM) domains are essential for coordinating intermolecular communication within nonribosomal peptides synthetases (NRPSs) complexes. Different sets of COM domains provide selectivity, allowing NRPSs to utilise different natural biosynthetic templ...

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Bibliographic Details
Main Authors: Hongxia Liu, Ling Gao, Jinzhi Han, Zhi Ma, Zhaoxin Lu, Chen Dai, Chong Zhang, Xiaomei Bie
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Microbiology
Subjects:
lipopeptide
NRPS
Plipastatin
biosynthetic complex
COM domain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01801/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01801/full

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