Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.

Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.

Neurosin is a protease that in vitro degrades α-synuclein, the main constituent of Lewy bodies found in brains of patients with synucleinopathy including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Several studies have reported reduced cerebrospinal fluid (CSF) levels of α-syn...

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Bibliographic Details
Main Authors: Malin Wennström, Yulia Surova, Sara Hall, Christer Nilsson, Lennart Minthon, Fredrik Boström, Oskar Hansson, Henrietta M Nielsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3540093?pdf=render

Internet

http://europepmc.org/articles/PMC3540093?pdf=render

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