Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload

Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload

RationaleGq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although mechano-sensitive channel activation by a variety of mechanisms has also been proposed, and the relative importance of calcineurin- and ca...

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Bibliographic Details
Main Authors: Ze-Yan Yu, Hutao Gong, Jianxin Wu, Yun Dai, Scott H. Kesteven, Diane Fatkin, Boris Martinac, Robert M. Graham, Michael P. Feneley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pressure overload induced hypertrophy
Gq receptors
calcineurin
CaMKIIδ
neurohumoral stimulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.639509/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.639509/full

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