In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

Abstract Background Resistance of Plasmodium falciparum against common anti-malarial drugs emphasizes the need of alternative and more effective drugs. Synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine have showed in vitro anti-plasmodial activities. The present stud...

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Bibliographic Details
Main Authors: Azar Tahghighi, Seyed-Mahdi Mohamadi-Zarch, Hamzeh Rahimi, Mahya Marashiyan, Naseh Maleki-Ravasan, Ali Eslamifar
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Malaria Journal
Subjects:
Anti-plasmodial activity
Docking study
Quinoline
Quinazoline
Plasmodium berghei
Histopathology
Online Access:http://link.springer.com/article/10.1186/s12936-020-03269-7

Internet

http://link.springer.com/article/10.1186/s12936-020-03269-7

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