Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.

Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for presently incurable advanced neoplasias with syste...

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Bibliographic Details
Main Authors: Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3131271?pdf=render

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http://europepmc.org/articles/PMC3131271?pdf=render

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