A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.

A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.

Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia. A signaling pathway downstream from the α7 nAChRs, which involves the collabor...

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Bibliographic Details
Main Authors: Maria C Maldifassi, Gema Atienza, Francisco Arnalich, Eduardo López-Collazo, Jose L Cedillo, Carolina Martín-Sánchez, Anna Bordas, Jaime Renart, Carmen Montiel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4178160?pdf=render

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http://europepmc.org/articles/PMC4178160?pdf=render

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