Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-<i>ij</i>]Quinolin-2(1<i>H</i>)-one as New Inhibitors of Factor Xa and Factor XIa

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-<i>ij</i>]Quinolin-2(1<i>H</i>)-one as New Inhibitors of Factor Xa and Factor XIa

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their inhibitors can serve as effective anticoagulant drugs. In the present work, we focused on the structure–activity relationships of derivatives of pyrro...

Full description

Bibliographic Details
Main Authors: Nadezhda Novichikhina, Ivan Ilin, Anna Tashchilova, Alexey Sulimov, Danil Kutov, Irina Ledenyova, Mikhail Krysin, Khidmet Shikhaliev, Anna Gantseva, Ekaterina Gantseva, Nadezhda Podoplelova, Vladimir Sulimov
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
pyrroloquinolinones
anticoagulants
molecular docking
factor Xa
factor XIa
Online Access:https://www.mdpi.com/1420-3049/25/8/1889

Internet

https://www.mdpi.com/1420-3049/25/8/1889

Similar Items