SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment.

SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment.

Treatment with tyrosine kinase inhibitors is the standard of care for Philadelphia chromosome positive leukemias. However the eradication of leukemia initiating cells remains a challenge. Circumstantial evidence suggests that the cytokine microenvironment may play a role in BCR-ABL mediated leukemog...

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Bibliographic Details
Main Authors: Özlem Demirel, Olivier Balló, Pavankumar N G Reddy, Olesya Vakhrusheva, Jing Zhang, Astrid Eichler, Ramona Fernandes, Susanne Badura, Hubert Serve, Christian Brandts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5533340?pdf=render

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http://europepmc.org/articles/PMC5533340?pdf=render

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