Reversal of Enantioselectivity in the Conjugate Addition Reaction of Cyclic Enones with the CuOTf/Azolium Catalytic System

Hydroxyamide-functionalized azolium salt (NHC•HI <b>4</b>) was evaluated for dual enantioselective control in a Cu-catalyzed asymmetric conjugate addition (ACA) reaction. This investigation was based on our previously reported ACA reaction catalyzed using CuOTf combined with NHC•AgI comp...

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Bibliographic Details
Main Authors: Yuki Nakano, Satoki Shimizu, Chihiro Takeda, Satoshi Sakaguchi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/26/11/3404