Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes
Objective: Postprandial fluxes in oxidative stress, inflammation, glucose, and lipids, particularly after a high-fat meal (HFM), have been implicated in the development of cardiovascular disease (CVD). The aim of this study is to determine whether acute freeze-dried mango consumption modulates the p...
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doaj-04cb378815fd461daffd76641bc098032020-11-25T03:35:03ZengSAGE PublishingNutrition and Metabolic Insights1178-63882019-08-011210.1177/1178638819869946Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant EnzymesCrystal O’Hara0Babajide Ojo1Sam R Emerson2Ashley J Simenson3Sandra Peterson4Penelope Perkins-Veazie5Mark E Payton6Janice Hermann7Brenda J Smith8Edralin A Lucas9Department of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Horticultural Science, North Carolina State University, Kannapolis, NC, USADepartment of Statistics, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USADepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK, USAObjective: Postprandial fluxes in oxidative stress, inflammation, glucose, and lipids, particularly after a high-fat meal (HFM), have been implicated in the development of cardiovascular disease (CVD). The aim of this study is to determine whether acute freeze-dried mango consumption modulates the postprandial response to an HFM. We hypothesized that the addition of mango, which is a rich source of many bioactive components, to an HFM would lower postprandial triglycerides, glucose, and inflammation, and increase antioxidant enzymes, compared to a standard HFM alone. Methods: In a randomized cross-over study, 24 healthy adult males (18-25 years old) consumed a typical American breakfast (670 kcal; 58% fat) with or without the freeze-dried mango pulp (50 g). Lipids, glucose, antioxidant enzymes, and inflammatory markers were assessed at baseline/fasting and 1, 2, and 4 hours after the HFM. Results: Addition of mango resulted in lower glucose (95.8 ± 4.4 mg/dL; P = .002) and higher high-density lipoprotein cholesterol (HDL-C; 58.4 ± 2.7 mg/dL; P = .01) 1 hour post-HFM compared to control (glucose: 104.8 ± 5.4 mg/dL; HDL-C: 55.2 ± 2.3 mg/dL), although no differences were observed in triglycerides ( P = .88 for interaction). No significant meal × time interactions were detected in markers of inflammation (C-reactive protein, P = .17; interleukin-6, P = .30) or antioxidant enzymes (superoxide dismutase, P = .77; glutathione peroxidase, P = .36; catalase, P = .32) in the postprandial period. Conclusions: When added to an HFM, acute mango consumption had modest beneficial effects on postprandial glucose and HDL-C responses, but did not alter triglyceride, inflammatory, or antioxidant enzymes.https://doi.org/10.1177/1178638819869946 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Crystal O’Hara Babajide Ojo Sam R Emerson Ashley J Simenson Sandra Peterson Penelope Perkins-Veazie Mark E Payton Janice Hermann Brenda J Smith Edralin A Lucas |
spellingShingle |
Crystal O’Hara Babajide Ojo Sam R Emerson Ashley J Simenson Sandra Peterson Penelope Perkins-Veazie Mark E Payton Janice Hermann Brenda J Smith Edralin A Lucas Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes Nutrition and Metabolic Insights |
author_facet |
Crystal O’Hara Babajide Ojo Sam R Emerson Ashley J Simenson Sandra Peterson Penelope Perkins-Veazie Mark E Payton Janice Hermann Brenda J Smith Edralin A Lucas |
author_sort |
Crystal O’Hara |
title |
Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes |
title_short |
Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes |
title_full |
Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes |
title_fullStr |
Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes |
title_full_unstemmed |
Acute Freeze-Dried Mango Consumption With a High-Fat Meal has Minimal Effects on Postprandial Metabolism, Inflammation and Antioxidant Enzymes |
title_sort |
acute freeze-dried mango consumption with a high-fat meal has minimal effects on postprandial metabolism, inflammation and antioxidant enzymes |
publisher |
SAGE Publishing |
series |
Nutrition and Metabolic Insights |
issn |
1178-6388 |
publishDate |
2019-08-01 |
description |
Objective: Postprandial fluxes in oxidative stress, inflammation, glucose, and lipids, particularly after a high-fat meal (HFM), have been implicated in the development of cardiovascular disease (CVD). The aim of this study is to determine whether acute freeze-dried mango consumption modulates the postprandial response to an HFM. We hypothesized that the addition of mango, which is a rich source of many bioactive components, to an HFM would lower postprandial triglycerides, glucose, and inflammation, and increase antioxidant enzymes, compared to a standard HFM alone. Methods: In a randomized cross-over study, 24 healthy adult males (18-25 years old) consumed a typical American breakfast (670 kcal; 58% fat) with or without the freeze-dried mango pulp (50 g). Lipids, glucose, antioxidant enzymes, and inflammatory markers were assessed at baseline/fasting and 1, 2, and 4 hours after the HFM. Results: Addition of mango resulted in lower glucose (95.8 ± 4.4 mg/dL; P = .002) and higher high-density lipoprotein cholesterol (HDL-C; 58.4 ± 2.7 mg/dL; P = .01) 1 hour post-HFM compared to control (glucose: 104.8 ± 5.4 mg/dL; HDL-C: 55.2 ± 2.3 mg/dL), although no differences were observed in triglycerides ( P = .88 for interaction). No significant meal × time interactions were detected in markers of inflammation (C-reactive protein, P = .17; interleukin-6, P = .30) or antioxidant enzymes (superoxide dismutase, P = .77; glutathione peroxidase, P = .36; catalase, P = .32) in the postprandial period. Conclusions: When added to an HFM, acute mango consumption had modest beneficial effects on postprandial glucose and HDL-C responses, but did not alter triglyceride, inflammatory, or antioxidant enzymes. |
url |
https://doi.org/10.1177/1178638819869946 |
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