Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 axis.

Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 axis.

IL-23 regulates myriad processes in the innate and adaptive immune systems, and is a critical mediator of the proinflammatory effects exerted by Th17 cells in many diseases. In this study, we investigated whether and how hepatitis B virus (HBV) causes liver damage directly through the IL-23 signalin...

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Bibliographic Details
Main Authors: Qinghong Wang, Jijun Zhou, Bei Zhang, Zhiqiang Tian, Jun Tang, Yanhua Zheng, Zemin Huang, Yi Tian, Zhengcai Jia, Yan Tang, Jennifer C van Velkinburgh, Qing Mao, Xiuwu Bian, Yifang Ping, Bing Ni, Yuzhang Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3694858?pdf=render

Internet

http://europepmc.org/articles/PMC3694858?pdf=render

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