Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

Protein tyrosine phosphatase 1B (PTP1B) regulates leptin signaling in hypothalamic neurons via the JAK2-STAT3 pathway. PTP1B has also been implicated in the regulation of inflammation in the periphery. However, the role of PTP1B in hypothalamic inflammation, which is induced by a high-fat diet (HFD)...

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Bibliographic Details
Main Authors:	Taku Tsunekawa, Ryoichi Banno, Akira Mizoguchi, Mariko Sugiyama, Takashi Tominaga, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Yoshihisa Sugimura, Hiroshi Arima
Format:	Article
Language:	English
Published:	Elsevier 2017-02-01
Series:	EBioMedicine
Subjects:	Protein tyrosine phosphatase-1B Hypothalamic inflammation High fat diet Microglia Obesity Signal transducer and activator of transcription-3
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396417300075

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http://www.sciencedirect.com/science/article/pii/S2352396417300075

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

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