Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in <i>LMNA</i>. A G608G mutation in exon 11 of <i>LMNA</i> is responsible for most HGPS cases, generating a truncated protein called “progerin”. Progerin is permanently farnesyl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/1/153 |