Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins. PARPs are known to function in a large range of cellular processes including DNA repair, DNA replication, transcription and modulati...

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Bibliographic Details
Main Authors: Daniel Harrision, Polly Gravells, Ruth Thompson, Helen E. Bryant
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
poly(ADP-ribose)polymerase (PARP)
poly(ADP-ribose)glycohydrolase (PARG)
synthetic lethality
chemosensitization
radiosensitization
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00191/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00191/full

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