TGFβ1, TNFα, and insulin signaling crosstalk in regulation of the rat cholesterol 7α-hydroxylase gene expression*

TGFβ1, TNFα, and insulin signaling crosstalk in regulation of the rat cholesterol 7α-hydroxylase gene expression*

The TGFβ1/Smad pathway plays a critical role in cholestasis and liver fibrosis. Previous studies show that TGFβ1, TNFα, and insulin inhibit cholesterol 7α-hydroxylase (CYP7A1) gene transcription and bile acid synthesis in human hepatocytes. In this study, we investigated insulin, TGFβ1, and TNFα reg...

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Bibliographic Details
Main Authors: Tiangang Li, Huiyan Ma, John Y.L. Chiang
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Journal of Lipid Research
Subjects:
CYP7A1
bile acid synthesis
liver fibrosis
nuclear receptors
Smad
FoxO1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520346666

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http://www.sciencedirect.com/science/article/pii/S0022227520346666

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