Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

Objective: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we discovered an unexpected weight loss phenotype. The o...

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Bibliographic Details
Main Authors: Kristin M. McCabe, Joanne Hsieh, David G. Thomas, Matthew M. Molusky, Liana Tascau, Jun B. Feranil, Li Qiang, Anthony W. Ferrante, Jr., Alan R. Tall
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300181

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http://www.sciencedirect.com/science/article/pii/S2212877820300181

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