Des-γ-Carboxy Prothrombin (DCP) as a Potential Autologous Growth Factor for the Development of Hepatocellular Carcinoma

Des-γ-Carboxy Prothrombin (DCP) as a Potential Autologous Growth Factor for the Development of Hepatocellular Carcinoma

Des-γ-carboxy prothrombin (DCP) is a prothrombin precursor produced in hepatocellular carcinoma (HCC). Because of deficiency of vitamin K or γ-glutamyl carboxylase in HCC cells, the 10 glutamic acid (Glu) residues in prothrombin precursor did not completely carboxylate to &#947...

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Bibliographic Details
Main Authors: Yu-Sheng Zhang, Jia-Hui Chu, Shu-Xiang Cui, Zhi-Yu Song, Xian-Jun Qu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Autologous growth factor
Hepatocellular carcinoma (HCC)
Angiogenesis
Signaling pathways
Des-γ-carboxy prothrombin (DCP)
Paracrine factor
Stimulation
Online Access:http://www.karger.com/Article/FullText/366308

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