Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation

Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation

Through neutron reflectometry and NMR spectroscopy studies, Mushtaq et al study the full-length Bcl-2 protein reconstituted in lipid bilayers. They find that, in contrast to previously studied truncated, soluble protein versions, intact Bcl-2 is mainly embedded in the membrane with its regulatory lo...

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Bibliographic Details
Main Authors: Ameeq Ul Mushtaq, Jörgen Ådén, Luke A. Clifton, Hanna Wacklin-Knecht, Mario Campana, Artur P. G. Dingeldein, Cecilia Persson, Tobias Sparrman, Gerhard Gröbner
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02032-1

Internet

https://doi.org/10.1038/s42003-021-02032-1

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