Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

The indoleamine 2,3-dioxygenase (IDO) enzyme can act as an immunoregulator by inhibiting T cell function via the degradation of the essential amino acid tryptophan (trp) into kynurenine (kyn) and its derivates. The kyn/trp ratio in serum is a prognostic factor for cervical cancer patients; however,...

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Bibliographic Details
Main Authors: A. Marijne Heeren, Ilse van Dijk, Daniella R. A. I. Berry, Maryam Khelil, Debbie Ferns, Jeroen Kole, René J. P. Musters, Victor L. Thijssen, Constantijne H. Mom, Gemma G. Kenter, Maaike C. G. Bleeker, Tanja D. de Gruijl, Ekaterina S. Jordanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
cervical cancer
indoleamine 2,3-dioxygenase
kynurenine
tryptophan
serum
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01598/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01598/full

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