Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation

Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation

Background: In the brain, polyamines are mainly synthesized in neurons, but preferentially accumulated in astrocytes, and are proposed to be involved in neurodegenerative/neuroinflammatory disorders and neuron injury. A transgenic mouse overexpressing spermine oxidase (SMOX, which specifically oxidi...

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Bibliographic Details
Main Authors: Chiara Cervetto, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Simone Pelassa, Stefano Giuliani, Francesca Baldini, Guido Maura, Paolo Mariottini, Manuela Marcoli, Manuela Cervelli
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
astrocyte processes
nerve terminals
excitotoxicity
oxidative stress
polyamines
spermine oxidase (SMOX)
Online Access:https://www.mdpi.com/2218-273X/11/9/1274

Internet

https://www.mdpi.com/2218-273X/11/9/1274

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