Molecular basis of human CD22 function and therapeutic targeting
The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00836-6 |