Cancer‐associated fibroblasts show heterogeneous gene expression and induce vascular endothelial growth factor A (VEGFA) in response to environmental stimuli

Cancer‐associated fibroblasts show heterogeneous gene expression and induce vascular endothelial growth factor A (VEGFA) in response to environmental stimuli

Abstract Aim Cancer‐associated fibroblasts (CAF) play a crucial role in angiogenesis in the complex tumor microenvironment. However, fibroblasts show extensive heterogeneity and their dynamic functions against stressors remain largely unknown. Methods We collected patient‐derived CAF and carried out...

Full description

Bibliographic Details
Main Authors: Ken‐ichi Inoue, Satoko Kishimoto, Kazumi Akimoto, Masashi Sakuma, Shigeru Toyoda, Teruo Inoue, Ken‐ichiro Yoshida, Mitsugi Shimoda, Shuji Suzuki
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Annals of Gastroenterological Surgery
Subjects:
cancer‐associated fibroblast
complex system
heterogeneity
perturbation
VEGF‐A
Online Access:https://doi.org/10.1002/ags3.12249

Internet

https://doi.org/10.1002/ags3.12249

Similar Items