Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe‐Dnmts axis

Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe‐Dnmts axis

DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells while decreasing their doubling time. Here, we show that incubation of prostate...

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Bibliographic Details
Main Authors: Vladislav Strmiska, Petr Michalek, Zuzana Lackova, Roman Guran, Sona Krizkova, Lucie Vanickova, Ondrej Zitka, Marie Stiborova, Tomas Eckschlager, Borivoj Klejdus, Dalibor Pacik, Eliska Tvrdikova, Claudia Keil, Hajo Haase, Vojtech Adam, Zbynek Heger
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Molecular Oncology
Subjects:
DNA methylation
Dnmts
epigenetics
prostate cancer
SAMe
sarcosine
Online Access:https://doi.org/10.1002/1878-0261.12439

Internet

https://doi.org/10.1002/1878-0261.12439

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