A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.

Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a neurodegenerative disorder with a poorly understood molecular mechanism. It is caused by mutations in Pantothenate Kinase, the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. Here, we developed a Drosophila model of PKAN (tim-fb...

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Bibliographic Details
Main Authors: Varun ePandey, Hagit eTurm, Uriya eBekenstein, Sagiv eShifman, Sebastian eKadener
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Drosophila
circadian
NBIA
PKAN
PanK
CoA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00146/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00146/full

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