Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

Abstract Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels; however, it remains unknown whether ade...

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Bibliographic Details
Main Authors: Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink
Format: Article
Language:English
Published: BMC 2018-05-01
Series:The Journal of Headache and Pain
Subjects:
Adenosine receptor
CGS21680
Dural vasodilation
Rat, vasodepressor response
Online Access:http://link.springer.com/article/10.1186/s10194-018-0867-x

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http://link.springer.com/article/10.1186/s10194-018-0867-x

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