The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

Aluminum (Al) is considered a pathological factor for various neurological and neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The neurotoxicity of aluminum can cause oxidative brain damage, trigger apoptosis, and ultimately cause irreversible damage to neu...

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Bibliographic Details
Main Authors: Jing Lu, Qingxia Huang, Dongmei Zhang, Tianye Lan, Ying Zhang, Xiaolei Tang, Peng Xu, Dexi Zhao, Deyu Cong, Daqing Zhao, Liwei Sun, Xiangyan Li, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
DiDang Tang
neuroprotection
oxidative stress
apoptosis
aluminum
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00466/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00466/full

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