A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats

A New Oleanolic Acid Derivative against CCl4-Induced Hepatic Fibrosis in Rats

A novel hepatoprotective oleanolic acid derivative, 3-oxours-oleana-9(11), 12-dien-28-oic acid (Oxy-Di-OA), has been reported. In previous studies, we found that Oxy-Di-OA presented the anti-HBV (Hepatitis B Virus) activity (IC50 = 3.13 µg/mL). Remarkably, it is superior to lamivudine in the inhibit...

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Bibliographic Details
Main Authors: Hongjun Xiang, Yaotian Han, Yuzhong Zhang, Wenqiang Yan, Bing Xu, Fuhao Chu, Tianxin Xie, Menglu Jia, Mengmeng Yan, Rui Zhao, Penglong Wang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:International Journal of Molecular Sciences
Subjects:
oleanolic acid derivative
carbon tetrachloride-induced
liver fibrosis
histological study
acute toxic test
pharmacokinetic
Online Access:http://www.mdpi.com/1422-0067/18/3/553

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http://www.mdpi.com/1422-0067/18/3/553

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