CD161+CD4+ T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and Interferon-gamma

CD161+CD4+ T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and Interferon-gamma

Hepatitis C virus infection is a major cause of chronic liver disease. CD4+ T cells play a key role in disease outcome. However, the critical functions and associated phenotypes of intrahepatic CD4+ T cells are not well defined. We have previously shown that CD8+ T cells expressing the C type lectin...

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Bibliographic Details
Main Authors: Yu-Hoi eKang, Bianca eSeigel, Bertram eBengsch, Vicki eFleming, Eva eBillerbeck, Ruth eSimmons, Lucy eWalker, Chris eWillberg, Eleanor J Barnes, Anisha eBhagwanani, Ye eOo, Hubert eBlum, David eAdams, Robert eThimme, Paul eKlenerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Immunology
Subjects:
Hepatitis C
Interleukin-17
Liver
CD4+ T cells
interleukin-22
CD161
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00346/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00346/full

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