Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification

Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification

Esophageal adenocarcinoma (EAC) is one of the most lethal malignancies, and limits promising treatments. AKR1C3 represents a therapeutic target to combat the resistance in many cancers. However, the molecular mechanism of AKR1C3 in the chemotherapy resistance of EAC is still unclear. We found that t...

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Bibliographic Details
Main Authors: Chenghui Zhou, Zhefang Wang, Jiahui Li, Xiaolin Wu, Ningbo Fan, Dai Li, Fanyu Liu, Patrick S. Plum, Sascha Hoppe, Axel M. Hillmer, Alexandar Quaas, Florian Gebauer, Seung-Hun Chon, Christiane J. Bruns, Yue Zhao
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
esophageal adenocarcinoma
AKR1C3
chemotherapy resistance
AKT signaling
ROS regulation
prognosis
Online Access:https://www.mdpi.com/2072-6694/13/10/2403

Internet

https://www.mdpi.com/2072-6694/13/10/2403

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