Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma via ROS Detoxification
Esophageal adenocarcinoma (EAC) is one of the most lethal malignancies, and limits promising treatments. AKR1C3 represents a therapeutic target to combat the resistance in many cancers. However, the molecular mechanism of AKR1C3 in the chemotherapy resistance of EAC is still unclear. We found that t...
Main Authors: | Chenghui Zhou, Zhefang Wang, Jiahui Li, Xiaolin Wu, Ningbo Fan, Dai Li, Fanyu Liu, Patrick S. Plum, Sascha Hoppe, Axel M. Hillmer, Alexandar Quaas, Florian Gebauer, Seung-Hun Chon, Christiane J. Bruns, Yue Zhao |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/10/2403 |
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