Fenofibrate reduces intestinal cholesterol absorption via PPARα-dependent modulation of NPC1L1 expression in mouse

Fenofibrate reduces intestinal cholesterol absorption via PPARα-dependent modulation of NPC1L1 expression in mouse

Fibrates, including fenofibrate, exert their biological effects by binding peroxisome proliferator-activated receptor α (PPARα), a member of the nuclear receptor superfamily of ligand-activated transcription factors. Treatment with PPARα agonists enhances fatty acid oxidation, decreases plasma trigl...

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Bibliographic Details
Main Authors: Mark A. Valasek, Stephen L. Clarke, Joyce J. Repa
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
dietary cholesterol
fractional cholesterol absorption
fecal dual-isotope method
real-time polymerase chain reaction
peroxisome proliferator-activated receptor α
Niemann-Pick C1-Like 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520429232

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http://www.sciencedirect.com/science/article/pii/S0022227520429232

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