Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips

Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips

Microbial cells in industrial large-scale bioreactors are exposed to fluctuating conditions, e.g., nutrient concentration, dissolved oxygen, temperature, and pH. These inhomogeneities can influence the cell physiology and metabolism, e.g., decelerate cell growth and product formation. Microfluidic s...

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Bibliographic Details
Main Authors: Phuong Ho, Christoph Westerwalbesloh, Eugen Kaganovitch, Alexander Grünberger, Peter Neubauer, Dietrich Kohlheyer, Eric von Lieres
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Microorganisms
Subjects:
microfluidics
single-cell analysis
modelling
simulation
computational fluid dynamics
frequency response
life line
monolayer growth chamber
mother machine
negative dielectrophoresis
Online Access:https://www.mdpi.com/2076-2607/7/4/105

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https://www.mdpi.com/2076-2607/7/4/105

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