Defining the role of NG2-expressing cells in experimental models of multiple sclerosis. A biofunctional analysis of the neurovascular unit in wild type and NG2 null mice.

Defining the role of NG2-expressing cells in experimental models of multiple sclerosis. A biofunctional analysis of the neurovascular unit in wild type and NG2 null mice.

During experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis associated with blood-brain barrier (BBB) disruption, oligodendrocyte precursor cells (OPCs) overexpress proteoglycan nerve/glial antigen 2 (NG2), proliferate, and make contacts with the microvessel wall. To explo...

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Bibliographic Details
Main Authors: Francesco Girolamo, Mariella Errede, Giovanna Longo, Tiziana Annese, Carlotta Alias, Giovanni Ferrara, Sara Morando, Maria Trojano, Nicole Kerlero de Rosbo, Antonio Uccelli, Daniela Virgintino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213508

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https://doi.org/10.1371/journal.pone.0213508

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