NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation

NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 provides an IEC-intrinsic protection against colitis-associated carc...

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Bibliographic Details
Main Authors: Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301875

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http://www.sciencedirect.com/science/article/pii/S2211124716301875

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