TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex

TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signaling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain...

Full description

Bibliographic Details
Main Authors: Dario Zimmerli, Costanza Borrelli, Amaia Jauregi-Miguel, Simon Söderholm, Salome Brütsch, Nikolaos Doumpas, Jan Reichmuth, Fabienne Murphy-Seiler, MIchel Aguet, Konrad Basler, Andreas E Moor, Claudio Cantù
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
wnt signalling
development
transcription
gene regulation
limb development
colorectal cancer
Online Access:https://elifesciences.org/articles/58123

Internet

https://elifesciences.org/articles/58123

Similar Items